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Description
Uroplakin III Recombinant Rabbit mAb (SDT-R177)Product Specification Host Rabbit Antigen Uroplakin III Synonyms Uroplakin 3a, UP3a, UPIII Location Endoplasmic reticulum membrane Accession O75631 Clone Number SDT R177 Antibody Type Recombinant mAb Application IHC P Reactivity Hu Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | Uroplakin III |
| Synonyms | Uroplakin-3a, UP3a, UPIII |
| Location | Endoplasmic reticulum membrane |
| Accession | O75631 |
| Clone Number | SDT-R177 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:1000 | null |
Background
Uroplakin III is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full. Uroplakin III can be expressed in primary and invasive bladder epithelial carcinomas, but is not expressed in many non-urothelial tumors, thus contributing to the research of bladder epithelial carcinoma. The Uroplakin III gene is deleted in normal urothelium and in bladder cancer after malignant metastasis, which can manifest as urothelial tumors with malignant tendencies and can be used as a reference for cell differentiation of urothelial cells. Uroplakin III-positive bladder epithelial cancer patients have a high relative survival rate.
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